Immunoglobulins in Protein-Calorie Malnutrition

term 'familial' does not seem to apply to such a situation. While Tandler's faulty recanalization concept may be of lesser importance in explaining atresias beyond the duodenum (where no 'solid stage' has been satisfactorily demonstrated), it may well apply to duodenal atresias. This is supported by the observation that it may be accompanied by other errors of growth, notably Down's syndrome (Bodian et al., 1952). This prompted us to search for a chromosomal aberration, but the karyotype studied was normal. The occurrence in three consecutive sibs of an uncommon condition such as duodenal atresia strongly suggests genetic determination. The parents being first cousins, it is possible that we are dealing with an autosomal recessive gene.